Tadalista 5 Mg is a prescription medication used to treat erectile dysfunction. Tadalista works by blocking the activity of PDE5, an enzyme that destroys a substance called cGMP. By blocking PDE5, cGMP is preserved and levels of cGMP increase. This causes relaxation of the smooth muscle cells lining the blood vessels in the penis, which increases blood flow to the penis. Tadalista can be taken as needed, 30 minutes before sexual activity. Tadalista can be taken with or without food. ...