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What must you know about Oxycodone medicine before starting the course of the medication? The FDA approved the first oxycodone-containing product, Percodan, on April 12, 1950. Oxycodone is a semisynthetic opioid painkiller emanated from thebaine in Germany in 1917.  It is currently known as an immediate release product for moderate to severe pain and as an extended-release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.    In...